MOTS-c What it is : Mitochondrial-derived peptide (16 amino acids) Mechanism : Enhances mitochondrial function Improves metabolic efficiency Increases NAD+ utilization Regulates energy metabolism Benefits : Improved energy and endurance Enhanced fat burning Better insulin sensitivity Increased exercise capacity Metabolic optimization Dosing : 5-10mg 2-3x weekly Cost : $80-150 per month Best for : Athletes, metabolic health, energy optimization Humanin What it is : Mitochondrial-derived peptide (24 amino acids) Mechanism : Protects mitochondria from stress Enhances NAD+ pathways Neuroprotective effects Anti-inflammatory Benefits : Cognitive protection Neuroprotection Metabolic benefits Longevity support Cellular stress resistance Dosing : 1-5mg daily Cost : $100-200 per month Best for : Cognitive health, neuroprotection, anti-aging SS-31 (Elamipretide) What it is : Mitochondrial-targeted tetrapeptide Mechanism : Concentrates in mitochondria Enhances ATP production Improves NAD+/NADH ratio Reduces oxidative stress Benefits : Enhanced cellular energy Improved mitochondrial function Cardioprotective effects Neuroprotective benefits Exercise performance Dosing : 5-10mg daily Cost : $150-250 per month Best for : Serious mitochondrial support, heart health, neurological conditions Note : Less commonly available, more expensive Cerebrolysin (indirect NAD+ support) What it is : Neurotrophic peptide complex Mechanism : Enhances brain-derived neurotrophic factor (BDNF) Supports mitochondrial function indirectly Neuroprotective Benefits : Cognitive enhancement Neuroprotection Recovery from brain injury Memory improvement Dosing : 5-10ml IM 2-3x weekly Cost : $200-400 per month Best for : Cognitive optimization, brain health, recovery from TBI Note : Not pure NAD+ booster but supports mitochondrial health Most accessible option: MOTS-c For most people : MOTS-c offers best balance of effectiveness, availability, and cost Second choice : Humanin for cognitive/neuroprotection focus Advanced users : SS-31 for maximum mitochondrial support MOTS-c dosing and protocols Most popular NAD+ peptide for general use
BPC-157 Arginate is a formulation that has enhanced stability in liquid, but standard handling and storage protocols are still the best practice to ensure maximum potency for research
We note that, over the past several years, the claims volumes for CPT codes 78431 and 78433 have increased significantly while the geometric mean costs of the codes have remained relatively stable
This enhanced cellular repair process means you can bounce back faster from tough workouts or a physically demanding day
When evaluating providers, look for: Peptide-specific experience: Many physicians lack training in this area
Int J Pharm 365: 121130, 2009
