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The effectiveness of the parent compound of reduced forms of antioxidants has been found to be affected by their major structural components, namely the sulfhydryl and hydroxyl groups

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Common side effects include local reactions at the injection site, hearing and vision impairment, and, less commonly, lung and kidney damage

In ferroptosis, GSH functions as a cofactor for GPX4 activation to mitigate lipid peroxidation and ROS accumulation, whereas it serves as a copper chaperone to inhibit lipoylated protein aggregation in the TCA cycle in cuproptosis ( GSH, a common biomarker of oxidative stress, may act as the intersection of ferroptosis and cuproptosis during periodontitis ( 3+

In concert with decreased IEC necroptosis, we observed reductions of portal blood LPS levels and suppression of inflammatory genes ( Tnfa, Il6, Il1b ) and SMA expression, as well as reduced collagen deposition in the liver

10.1016/j.artmed.2023.102690 13