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It has also been suggested that repair of the 2nd strand takes advantage of the two-fold symmetry of many short-range complexes, such that its ligation is mediated by the second of the two ligase molecules that were present in the initial complex 12,15

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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, huntington's, alzheimer's, prions, bactericides, chemical toxicology and others as examples