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TLR4 cell signaling induces both HK2 expression and phosphorylation in DCs by at least 2 pathways ( Intricate interactions between hepatitis viruses and TLRs have been reported with both activating and inhibiting effects ( via TLR2 ( Detection of viral components by cytosolic PRRs also triggers metabolic reprogramming in liver cell types ( Another important PRR that regulates metabolism is the stimulator of IFN genes protein (STING)

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Compared with POR, CYB5R1 has a lower ability to transfer electrons and produces H 2 O 2 -mediated lipid peroxidation

Indeed a comparison of GSH levels (Supplementary Figure S6) in the two wild-type strains show that ATCC26933 has lower GSH levels than AfS77, perhaps linked to the different levels of gliotoxin production

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