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After multiple introductions of CJC-1295, mean IGF-I levels appear to remain above baseline for up to 28 days

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Increases in plasma ascorbate were even observed in FIV-infected cats, in contrast to ascorbate deficiencies that have been observed in HIV-infected humans

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Importantly, mutant SOD1 has been demonstrated to decrease the expression of antioxidant transcription factor NRF2 and its dependent target genes in an established NSC134 cellular model for SOD1-associated ALS (Kirby et al., 2005)