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Interleukin 1 receptor-associated kinase 2 (IRAK2), which is highly expressed in PC, promotes the expressions of GLUT1, phosphoglucose isomerase (GPI1), and PDK1 by activating the immune-related pathway (NF-B), thereby increasing glucose consumption and lactate production in cancer cells, providing bioenergetic and metabolic requirements for their survival and proliferation (251)