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Description

Positive test results were obtained in the in vitro CHO sister chromatid exchange (clastogenicity) test, and in the mouse lymphoma cell (mutagenicity) assays, using concentrations of hydrochlorothiazide of 43 to 1300 mcg/mL

In HF-LPME, the organic liquid membrane is used as a surrogate for the biomembrane, and the acceptor concentration is a surrogate for the internal concentration