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To our knowledge, this is the first study analyzing both public and private healthcare systems in Brazil in relation to vitamin B 12 deficiency trends and hospitalizations

Moreover, brain-derived neurotrophic factor (BDNF), which is a crucial player for neurodevelopment and cognitive functions, showed lower levels in ACE2KO mice, with higher ATR1 expression and cognitive deficits [366]

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A single 100,000 IU injection can elevate serum 25-hydroxyvitamin D within four weeks and sustain sufficiency for up to three months, although individual kinetics vary with baseline depletion and body composition