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Cuprizone-brain damage and motoric disability The used cuprizone regimen, several times higher than those regularly used in cuprizone studies (62), rapidly induced marked functional disability along with severely affected various brain areas

Desulfovibrionales have genes for sulfate reduction that reduce sulfate to hydrogen sulfide, which results in enhancing farnesoid X receptor (FXR) in HepG2 cells and followed by CYP7A1 inhibition ( Further evidence linking drug metabolism and gut microbiome is research investigating how tacrolimus (TAC) pharmacokinetics were affected by gut microbiome using in vivo mice models

Association of oxidative stress to the genesis of anxiety: implications for possible therapeutic interventions

This key role of antioxidants on microbiota probably extends beyond the digestive tract, as the beneficial effect of butyrate has been suggested for other human microbial ecosystems, such as the skin 46 , the gut-brain axis 47 and atopic diseases 48

Pollution, smoking, lack of sleep, poor diet, and UV exposure all increase oxidative stress

doi: 10.1007/s00125-009-1402-z 47 JoJRAnSGhoshSNedumaranBKimYD