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10.2.4 Combination with coordinated undermining of survival paths DSF with aprepitant, auranofin, captopril, celecoxib, itraconazole, minocycline, quetiapine, and sertraline constituted a CUSP9 regimen that was used in combination with TMZ to synergistically disrupt the active survival pathway in GBM, block multiple signaling pathways, and make GBM vulnerable to the cytotoxic effects of TMZ (Skaga et al., 2019)

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Through DNA damage, lipid peroxidation, protein oxidation, and disturbed regulation of pro-apoptotic and anti-apoptotic factors [i.e

Goel et al., 2022)