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Similarly, an experiment on the overexpression of neuroligin 1 confirmed the association between changes in the ratio of two synaptic adhesion molecules, neuroligins and neurexins, and synaptic plasticity [59]

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Nuclear nicotinamide adenine dinucleotide deficiency by Nmnat1 deletion impaired hepatic insulin signaling, mitochondrial function, and hepatokine expression in mice fed a high-fat diet

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This is also consistent with the fact that metformins primary beneficial effect in type 2 diabetes is in the intestines [30]

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Boxmeer JC, et al