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These enzymes inactivate HIF-

Apoptosis in Autoimmune Diabetes: The Fate of Beta-Cells in the Cleft Between Life and Death

Research shows that IFN- can participate in the progress of T1D diseases through several pathways, which include mediating beta cell death by stimulating the cytotoxic CD8 T cells response (142)

2 Key regulatory mechanisms of EMT 2.1 Central role of TGF- superfamily signaling As a pleiotropic cytokine, transforming growth factor- (TGF-) exerts pivotal regulatory functions in pulmonary fibrosis via both Smad-dependent and Smad-independent pathways, driving epithelialmesenchymal transition (EMT) and promoting airway inflammation and remodeling ( The TGF-/Smad cascade also contributes to airway fibrosis through induction of amphiregulin (AREG), which activates EGFR signaling to enhance fibroblast proliferation and myofibroblast conversion

[Google Scholar] 95.Xiao S., De Zhang Z., Lu H., Jiang S., Liu H., Wang G., Xu G., Zhang Z., Lin G., Wang G

15 Again, genetic depletion of UCHL3 prevent these tumorigenic events