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We first confirmed that biallelic SORD mutations result in complete loss of the protein, whereas heterozygous mutations lead to reduced SORD expression

For example, resveratrol (plant-derived phytoalexin) treatment triggers a strong signal for autophagy (p62 accumulation) through JNK activation leading to death in imatinib-resistant chronic myelogenic leukemia cells (CML) [369, 370]

Repeat treatments are typically necessary, but results are usually effective

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PSs have a positive effect on Gastroesophageal reflux (GR), and dibasic sodium alginate has emerged as a promising therapeutic option, because in addition to protecting the esophageal mucosa and limiting gastric reflux into the esophagus, they also adhere to the gastric mucosa, protecting it and promoting its repair (113)