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The source of nitric oxide contributing to peroxynitrite formation within mitochondria, however, is not well characterized

Funding Statement This work was supported by Japan Science and Technology Agency (JST) CREST Grant Number JPMJCR2024 (20348438 to T.A.), Grant-in-Aid for Scientific Research on Innovative Areas(A) Sulfur biology (21H05263 and 21H05258 to T.A.), International Leading Research (23K20040 to T.A.), Scientific Research (S) (24H00063 to T.A.), from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and Japan Agency for Medical Research and Development (AMED) to T.A

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In controlled laboratory research environments, GHK-Cu is widely studied for its role in peptide-mediated signaling, copper-dependent molecular regulation, and cellular communication pathways