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Description

NNSMS contributed to designing the outlines of the literature study

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The disease is usually diagnosed in childhood and sometimes in early adulthood

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Pradhan et al., 2018)

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Importantly, daily pelargonidin administration to mice for 30 days induced no detectable adverse histological or inflammatory effects, suggesting a potentially safe mechanism to facilitate peptide absorption (Lamson et al., 2022)

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Supplements/Drugs Aloe [109] (in cancer cells) 5-HTP (at lower and higher concentrations) [110] Reishi [111] Grapeseed extract [112] in astrocytes, which is neuroprotective

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Analysis of the contribution of GSSG to the determined GSx contents for cells that had been treated without itaconate and its derivatives revealed that after a 6 h incubation, GSSG represented only around 3% of the determined cellular GSx and around 10% of the extracellular GSx (Table 1), demonstrating that GSH accounts for the large majority of intra and extracellular GSx contents and that the cells were not under any oxidative stress, consistent with literature data [34, 45]

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