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The study was a randomized, double-blinded, placebo-controlled, crossover trial---the gold standard for scientific trials

Calderon-Cabrera L, Duran-Galetta MG, Garcia I, Galetta D, Lacruz L, Naranjo R, Perez B, Ferreira E (2008) Determination of the N-acetylcysteine and methionine effects in the cerebellum of rats intoxicated with lead

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The oxidative stress caused by a decrease in GSH levels can then impact microglia function and potentially lead to a more pro-inflammatory M1 phenotype that has reduced -amyloid clearance capabilities (Vilhardt et al., 2017)

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