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Lipid-based DDSs (LBDDSs) utilize phospholipid bilayer architectures [e.g., liposomes, ethosomes, and solid lipid nanoparticles (SLNs)] to achieve localized drug enrichment in joint cavities or inflammatory foci, with reduced immunogenicity due to biomimetic membrane properties (Seo et al., 2023)

In this scenario, with some sacrifice on warhead reactivity (k inact ), a high overall efficacy (k eff ) can only be achieved through optimizing for the non-covalent binding contribution (reflected by inactivation constant K I ) [107]

Diabetes 47(4):507514

NSPs can promote the immune system, reduce inflammation ( Inhibitors of Enzymes The inhibitors of enzymes, including trypsin, chymotrypsin, carboxypeptidases, elastase, and -amylase, are important naturally occurring antinutritional factors

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