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Journal of Clinical Psychiatry, 79 , 17m11669

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From this diet, the LGSH and HGSH diets were prepared by replacing the corn with 0.1 and 1.0% GSH, respectively

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Although HLH-30 is known to be activated by oxidative stress (Lin et al, 2018), its role in ROS-mediated lifespan extension had not been previously investigated

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Thus, our findings are likely the result of the potent antioxidant capacity of GSH facilitating the engagement of accumbal circuitry to produce motivated behavior, as well as GSH-independent mechanisms involving more complex and long-term modifications, including a reshaping of synaptic glutamatergic activity

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