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In CAD, fatty plaques form and grow inside the blood vessels, causing severe inflammation

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In the supernatants, the concentrations of molecules IL-6, tPA, PAI-1, and vWF were measured with the standard ELISA kits (R&D Systems, Minneapolis, MN, USA)

Zhao W, Zhuang P, Chen Y, Wu Y, Zhong M, Lun Y

Diabetologia 56 (6), 14031412

Considering this, detected the expression levels of autophagy markers (LC3B and PINK1), antioxidative stress markers (SOD1 and GPx1), mitochondrial uncoupling proteins (UCP2, UCP4, and UCP5), and mitochondrial factors including pro-mitochondrial fission factors of dynamin-related protein 1 (DRP1) and its phosphorylated version of p-DRP1, the mitochondrial fission factor (MFF) in charge of pro-midzone-type fission, the mitochondrial fission 1 (FIS1) in charge of pro-peripheral-type fission, and pro-mitochondrial fusion factor mitofusin 2 (MFN2), in SNr and cerebral cortex)