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Alout H, Berthomieu A, Cui F, Tan Y, Berticat C, Qiao C, et al

McDowell JA, Chittick GE, Stevens CP, Edwards KD, Stein DS

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CAR chimeric antigen receptor Embodiment 214 A method of providing an anti-tumor immunity against tumors that express ALPP and/or ALPPL2, and/or a region of ALPP and/or ALPPL2 bound by antibody M25AD, M25ADX and/or M25 in a mammal, the method comprising administering to the mammal an effective amount of a cell genetically modified to express a chimeric antigen receptor (CAR) according to any one of embodiments 201-205, thereby providing an antitumor immunity in the mammal