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Aberrant glycosylation has been observed to affect a number of oncogenes during tumorigenesis, including EGFR, where increased glycan branching results in increased residency time at the plasma membrane, thus increasing its active period (Lajoie et al, 2007)

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173,174,175 Finally, mTORC1 controls ribosome concentration, affecting phase separation in the cytosol, 176 providing new insights into how cells balance efficient biosynthesis with the risk of molecular overcrowding

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Mice with excessive tumor burden at the start of an in vivo study, as indicated by swollen abdomen or low BCS, were removed from the study and euthanized as per ethical guidelines

10.1038/nature09857 Nature 157 KaliaM.SullivanJ