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Carnitine and acylcarnitines are exchanged between different tissues as metabolic intermediates or signaling molecules, directly or indirectly affecting a variety of metabolic and biological pathways in almost all organs, and have broad impacts on interorgan communication and metabolic cooperation

Urinary lactate serves as both an early diagnostic biomarker for hypoxic-ischemic encephalopathy in term infants and a strong predictor of long-term neurodevelopmental outcomes in preterm brain injury, potentially mediated by impaired cerebral energy metabolism during early neurodevelopment (Zasada et al

placebo group n = 12, 10 males and 2 females), in a double blind, placebo controlled crossover design

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(2010) Efficacy of combined topiramate/thioctic acid therapy in migraine prophylaxis

The elevation of glucose in the circulation leads to insulin synthesis that, when overproduced, finally results in peripheral insulin resistance, affecting adipose and muscle mass (Masi and Patel, 2021)