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General procedure and design This study used a within-subject design including screening, and two baseline assessments before treatment initiation (pretreatment), and one assessment at posttreatment

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Considering all this, its not too surprising that high levels of homocysteine have been linked to many chronic neurodegenerative and neuropsychiatric diseases, including: Depression (105-111) Dementia, Alzheimers disease , cognitive impairment/dysfunction/decline (119-133, 143) Headaches and migraines (112-118, 148) Hearing loss (136-137) Brain atrophy (134, 144, 151) Parkinsons disease (145) Stroke (154-155) Postpartum depression (135) Postmenopausal mental decline (146) Schizophrenia and other affective disorders (147, 153, 156) Alcoholism (149) Multiple sclerosis (158-161) People with nutritional deficiencies and MTHFR gene mutation are at an increased risk of high homocysteine levels

Gonzalez-Flores JN, Gupta N, DeMong LW, Copeland PR

This is reflected in the scarce therapies available for non-motor deficits (Zesiewicz et al., 2010)

Current approaches to overcome the side effects of GnRH analogs in the treatment of patients with uterine fibroids