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FIGURE 5 Hypoxia-Inducible Factor-3 mRNA Expression was Significantly Increased in Alzheimers Disease and Parkinsons Disease Due to the fact that T2D and neurodegeneration disease shared the overlapping pathophysiological mechanisms and pathways, we detected Mmp8 and Hif3 mRNA expression value in AD and PD samples by analyzing gene expression datasets in GEO

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The amount of HGF inhibitor that is administered may be in the range of from about 0.1 to about 1 ,000 mg/kg, an preferably in the range of from about 1 to about l OOmg/kg, although as one of skill in the art will recognize, the precise amount may vary depending on one or more attributes of the drug recipient, including but not limited to: weight, overall health, gender, age, nationality, genetic history, other conditions being treated, etc., and larger or smaller doses are within the practice of this invention

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