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Additional information Communicated by swati sharma Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations

References Godlewska BR, Williams S, Emir UE, Chen C, Sharpley AL, Goncalves AJ, et al

Reviews published in 2025 describe a body of research dominated by animal and cell studies, with signals suggesting effects on angiogenesis (the growth of blood vessels), growth-factor signalling (mainly growth hormone) and musculoskeletal healing

66 HalariR.SimicM.ParianteC

Enhanced sleep quality and overall energy levels

Standard protocols are once daily, typically at bedtime on an empty stomach (at least two hours after the last meal), to align with the natural overnight growth hormone pulse window