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Microbial systems, while advantageous for biopharmaceutical production, face challenges due to high-mannose N-glycosylation (Kulagina et al., 2021)

2012 Nov 21;104(22):1772]

In another related study by Sotillo et al

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adolescentis (21 strains), B

Intriguingly, two other Tdf proteins are present in pathogenic but in none of the commensal Neisseria species, TdfF and TdfG (Marri et al., 2010), suggesting a key role in virulence