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This model is based on insults that are recognized to contribute to the development of NEC in humans, including intestinal immaturity, hypoxia, and artificial hyperosmolar formula feeding

The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)

For instance, during the drug design phase, companies can discuss aspects such as the mechanism of action and potential risks with regulatory bodies to ensure that their research aligns with compliance expectations

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2-OG is a cofactor for a family of enzymes called 2-OG-dependent dioxygenases that catalyze the hydroxylation of a wide range of targets (190)