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First, S100A8/S100A9 promotes tumor cell growth through the activation of the NF-B signaling pathway in a RAGE-dependent manner (126), while S100A8/S100A9 can interact with RAGE (127)

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Autonomic Effects Blood pressure, heart rate, and tympanic body temperature were repeatedly measured 1 h before and 0, 0.5, 1, 1.5, 2.0, 2.5, 3, 3.5, 4, 5, 6, 7, 8, 9, 10, 11, 12, and 24 h after drug administration

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Funding This work did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors

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Niacin (vitamin B3) is a vitamin that can cause blood vessels to dilate, which is why it causes flushing in many people

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