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Addressing these issues is crucial for improving both mental and physical health in this population ( Shahmohammadi et al

One source of interference is the uncontrollable nature of nanoparticle aggregation and self-aggregation in complex samples, leading to high background signals and false-positive results

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For example, reduced hippocampal BDNF expressiona hallmark of ethanols neurotoxicity in rodentshas been corroborated in humans, with chronic drinkers showing 50% lower BDNF levels compared to controls

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Furthermore, size-based separation of EXOs is complicated by the existence of a significant amount of nanoparticles (some non-vesicular) that are identical in dimensions to EXOs