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Ethics declarations Competing interests SJW is the founder of Ridgeline Therapeutics, HN is a paid employee of Ridgeline Therapeutics and, since manuscript submission, ADW has also become a paid employee of Ridgeline Therapeutics

Based on this result, we further explored the mechanism of the drug pair from nuclear factor erythroid 2-related factor2/Hemeoxygenase-1(Nrf2/HO-1) pathway (Gong et al., 2017)

Supplementary material The Supplementary Material for this article can be found online at: FILE S1 | Sequences of glyoxalase I proteins from various species used for phylogenetic analysis of MtGLYI proteins