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The nature of the innate immune response in humanized mice requires further study

Heavy metals have also been linked to CVD through mechanisms involving apoptosis (38, 39, 40), endothelial dysfunction (41 ), and epigenetic effects (1, 42)

doi: 10.3390/ijerph17114135 138

Altered intestinal microbiota was closely connected to IR, with higher fat body weight and insulin levels in mice receiving feces from aged mice compared to mice receiving feces from adult mice (Binyamin et al., 2020)