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Figure 1 4.1 Activation of Toll-like receptors by dysbiotic microbiome affects esophageal barrier structure, epithelial repair, and triggers inflammatory responses involved in GERD G- bacteria are key producers of lipopolysaccharide (LPS), which abnormally activates a variety of Toll-like receptors (TLRs) leading to epithelial barrier dysfunction and inflammatory responses leading to GERD

Intestinal phase of gastric secretion', Journal of Experimental Physiology , 15,55-68

A highly conserved genomic area comprising over 60 genes involved in terminal keratinocyte differentiation is the Epidermal Differentiation Cluster (EDC), which is part of the PSORS4 locus on chromosome 1q21