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Thus, MAO-B-mediated astrocytic GABA synthesis and its involvement in neuronal tonic excitation augments synaptic transmission and regional metabolism, contributing to the development of neuropathic pain

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Genome-scale metabolic modeling reveals that Telaglenastat is uniquely suited to counter the adaptive metabolic reprogramming induced by Palbociclib To obtain a systems-wide perspective of the metabolic reprogramming underlying treatment with Palbociclib, Telaglenastat, or their combination, we integrated the transcriptomics and metabolomics data from the residual xenograft tumors in the framework of Recon3D

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