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In an environment with elevated CD38 activity, such as seen in SSc lesional skin, administering NAD + precursors or enhancing NAD + synthesis will have limited effect on increasing NAD + levels, as elevated CD38 continues to degrade NAD +

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AOD 9604 is a peptide derivative of human growth hormone (hGH) as it constitutes the short C-terminal 176-191 amino acid fragment (1)