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Through neural, immune, endocrine, and metabolic signaling pathways, the gut microbiome can influence brain physiology, while the brain can in turn modulate gut microbial composition via stress hormones and autonomic innervation [11, 12]

Carcinogenesis 29:102232 Natarajan VT, Singh A, Kumar AA (2010) Transcriptional upregulation of Nrf2-dependent phase II detoxification genes in the involved epidermis of vitiligo vulgaris

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444 Ongoing research also investigates EX-527s potential roles in improving other metabolic diseases, including endotoxemia, 445 diabetic nephropathy, 446 and infertility (NCT04184323) remains ongoing