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In BV-2 cells treated with fluoride, SOD levels decreased, while those of MDA, ROS, superoxide anions (O 2 ), and NOS significantly increased in a dose-dependent manner (Shuhua et al., 2012)

Nuclear transport, oxidative stress, and neurodegeneration

Uric acidlowering drugs in diabetes Considering UA as a target for prevention/management of diabetes is still premature and needs to be evaluated in clinical trials

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Next, the plants were treated with 200 M cycloheximide and total proteins were isolated at 0, 3 and 6 h from GSNO treated and non Cl pH 7.5, 150 mM NaCl, 0.5 % Triton_X_100 (v/v) and protease inhibitor, Thermo Scientific) at 4 C and centrifuged at 13,000 rpm for 30 min at 4C

Studies on diabetes treatment and prevention have mainly focused on investigating the oxidative stress mechanisms linked to diabetes and examining the effectiveness of antioxidants in averting these mechanisms