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doi: 10.1093/plphys/kiac113 74 ParkJ.LimC

To further expound on the fire metaphor, the result of not being able to neutralize the effects of ROS, is damage and, also, inflammation (literally the body is in flames)

Nitric oxide inhibition of cAMP synthesis in parotid acini: regulation of type 5/6 adenylyl cyclase

These are scars that are depressed, and can be grouped into the boxcar, icepick, or rolling categories, based on the shape of the scar indentation

Second, central to the "iron-dependent" nature of ferroptosis, ferrous ions (Fe 2 ) in the labile iron pool are the key catalysts for the Fenton reaction, which generates highly reactive hydroxyl radicals