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Additionally, the study aimed to explore the methyl-dependent epigenetic mechanisms that play a role in regulating these biomarkers as well as investigate the potential of vitamin B12 in modulating the gene expression of these genes in leukocytes

This results in decreased autophagy and increased apoptosis, contributing to Schwann cell dysfunction

The effects of the Tbx1 mutation on brain metabolism were analysed first by reporting the results obtained in PBS-treated Tbx1 +/ and WT brains, followed by those obtained in vB12-treated animals with the same genotypes

Vitamin B12 is involved in a lot of vital processes in the body

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