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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of c-MYC activity

Furthermore, reduced antioxidant enzyme activity promotes pro-inflammatory signaling pathways and activates hepatic stellate cells, driving liver fibrosis progression

Thus, further studies are needed in order to ascertain the functional role of these FPN/hepcidin regulators in modulating ferroptosis under pathological conditions

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doi: 10.1016/j.dld.2017.01.142 166 PittayanonRLauJTYuanYLeontiadisGITseFSuretteMet al

The researchers found distinct markers of compromised gut integrity, noting that fungal and bacterial products were actively leaking into the patients' bloodstreams