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Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase, can cross the blood-brain barrier, activating P126 and mitochondrial ROS production, restoring normal mitochondrial function in 53 out of 125 gliomas patients [81, 216, 217]

239 TomkovaM.McClellanM.KriaucionisS.Schuster-BoecklerB

In the exogenous apoptotic pathway, ROS promotes the formation of a death-inducing signal complex between adaptor protein FADD and procaspase-8/10 by activating death receptors such as TNF-R1, TRAIL-R1/2 and Fas

Rarely, individuals may experience an allergic reaction to the injection, characterized by difficulty breathing, hives, or swelling of the face, lips, or tongue

In murine xenografts, tumor growth inhibition, or regression in response to TLK286 was positively correlated with the level of GST P1-1 expression (Morgan et al., 1998)