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Adopting a microinjection approach to isolate GSSG elevation within the cell, this work identifies that GSSG can trigger neural HT4 cell death via a 12-lipoxygenase (12-Lox)-dependent mechanism

10.1093/toxsci/kfg095

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However, levels may be depleted by kidney disease, liver disease, genetic defects, valproic acid (an epilepsy drug), cancerand advancing age

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