glutathione biosensir An Overview of Biosensors Based on Transferases and for the Detection of Glutathione - Federici - 2021 - Electroanalysis Unlike regular glutathione Open chain conjugated azomethine derived

*Correspondence: Jianhong Zuo, [email protected] These authors have contributed equally to this work This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The enhanced glycolytic activity serves as a transient energy source, primarily sustaining the viability and limited functional capacity of the remaining TECs (van der Rijt et al., 2022)

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Intravitreal injection of neurotoxic astrocytes did not induce RGC neurodegeneration in the absence of neuronal injury, suggesting that injury and glial activation are required for neurodegeneration ( Crosstalk Between Mitochondrial Dysfunction and Inflammation Glaucoma is a complicated and progressive neurodegenerative disease where multiple pathways contribute to pathogenesis

Overall, our results indicate that the pHAT domains and their linkers regulate hOGA activity through allosteric modulation, stabilising a dynamic peptide-binding cleft and maintaining the dimerisation interface, which ensures proper substrate recognition and O-GlcNAc homoeostasis