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These losses lead to impaired axonal function, increased vulnerability of axons to damage, and result in significant brain atrophy and neuro-axonal degeneration

This evidence supports the roles of ghrelin mimetics in boosting hunger (helpful in calorie-surplus phases), activating the GH/IGF-1 axis, and potentially helping maintain or increase lean mass through anabolic signaling

Stranahan, A

Potential drug candidates therefore should target these toxic oligomers, by either inhibiting their formation or otherwise decrease their concentration

It may also be given in conjunction with lipotropics and phentermine