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The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway is crucial for cells to recognize and respond to cytosolic double-stranded DNA (dsDNA), serving as a primary driver for the establishment of innate immunity through the induction of IFN-I (11)

Upon viral infection, alveolar epithelial cells, macrophages, and blood circulating monocytes are activated via toll-like receptors as pattern recognition receptors (PRRs) by the virus products and produce a robust amount of inflammatory cytokines and chemokines, which attract more immune cells, in particular, monocytes and T cells, resulting in widespread lung inflammation (Fig

May 2011;25(5):570-578

Investigation of the effects of monomeric and dimeric stilbenoids on bacteria-induced cytokines and LPS-induced ROS formation in bone marrow-derived dendritic cells