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Stage 2: Decreased levels of B12 and metabolic abnormalities such as high homocysteine or methylmalonic acid (MMA) levels

In fact, over 14,000 new cases of anemia are reported annually in the elderly, underscoring the prevalence of this condition in this demographic

J Clin Oncol 41:373384

While challenges in translating findings from animal models to human patients due to differences in important factors such as IVD size, cell turnover, and biomechanical load need to be acknowledged and carefully considered, the usefulness of these experimental models cannot be ignored

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