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Vitamin D deficiency is strongly associated with myofascial pain syndrome and chronic pain muscle spasms, particularly in populations with limited sun exposure

Medicine 102 , e32653 (2023)

Dray, "B12 deficiency can cause graying of the hair as well as hyperpigmentation over your knuckles and your feet." Vitamin B12 is essential for red blood cell production, nerve health, and DNA synthesis, all of which play a role in healthy hair follicle function and pigment production

The body needs more B6 at exactly the time when dietary intake of B6 is dropping

As a consequence, more glucose is left available in extracellular compartment for the more hypoxic areas of the tumour [51]

SASP includes pro-inflammatory cytokines (IL-6, IL-8, TNF-), growth factors, and matrix metalloproteinases (MMPs), influencing the tissue microenvironment.19 While SASP plays roles in wound healing and tumor suppression, chronic SASP contributes to inflammation, fibrosis, and aging-related diseases.20 Epigenetic Regulation of Senescence: Chromatin remodeling through histone modifications and DNA methylation influences senescence