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Cilostazol is known to inhibit ROS, while curcumin is a well-established antioxidant and anti-inflammatory agent

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Unlike full-length growth hormone, which binds to growth hormone receptors and triggers IGF-1 production with associated anabolic effects, AOD9604 does not bind to the growth hormone receptor and does not stimulate IGF-1 production or promote cell proliferation

These include pharmacokinetic instability related to poor oral bioavailability and rapid metabolism, insufficient tissue-specific delivery to pelvic lesions, limited mechanistic validation in human-relevant 3D organoid and patient-derived xenograft models, a lack of standardized and clinically graded botanical preparations, and a shortage of large-scale randomized controlled trials evaluating efficacy, safety, and long-term outcomes across diverse patient populations

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He Z, Shen P, Feng L, Hao H, He Y, Fan G et al