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Pharmaceutics 17 (2), 210

Upon activation, these caspases cleave gasdermin D (GSDMD), which then binds to lipids at the plasma membrane and forms oligomeric pores, thereby leading to pyroptosis

HoFH in Adult and Pediatric Patients In an open-label, forced-titration study, HoFH patients (n=40, 8-63 years) were evaluated for their response to rosuvastatin 20 to 40 mg titrated at a 6-week interval

However, the described impairments of Tg4-42 mice cannot be attributed to an increased thigmotaxis as transgenic mice did not differ from WT animals in thigmotaxic swims, floating rate, or swimming speed

Beam breaks were recorded 1 h for habituation to locomotor chambers before mice received i.p

Most patients begin noticing changes in pain levels, range of motion, and recovery speed during the maintenance phase