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doi: 10.1146/annurev-pathol-052920-040318 158 JanoschkaCLindnerMKoppersNStarostLLiebmannMEschbornMet al

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It also necessitates multifactorial strategies to minimise the risk of possible acute and long-term complications such as neuropathy, retinopathy, and nephropathy and cardiovascular morbidities which are increased two-to-threefold in these patients and are subsequently a major cause of death

Recent breakthrough research has illuminated the critical role of oxidative stress and mitochondrial dysfunction in these conditions