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[DOI] [Google Scholar] 45.Altamura S., Schaeper U., Dames S., Lffler K., Eisermann M., Frauendorf C., Mdder K., Neves J., Muckenthaler M.U

Loss of CTLA-4 Leads to Massive Lymphoproliferation and Fatal Multiorgan Tissue Destruction, Revealing a Critical Negative Regulatory Role of CTLA-4

Beyond preventing necroptosis, ICP6 additionally suppresses apoptosis by directly binding to and inhibiting caspase-8

Single administration of thrombopoietin prevents progression of liver fibrosis and promotes liver regeneration after partial hepatectomy in cirrhotic rats

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By revealing the detailed immune activation mechanisms through single-cell sequencing, the study achieved simultaneous regression of primary and distant tumors, establishing a novel paradigm for radio-immunotherapy